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Protein TNKS2 PDB 3KR7.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesTNKS2, ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6, tankyrase 2
External IDsMGI: 1921743 HomoloGene: 11890 GeneCards: TNKS2
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TNKS2
Genomic location for TNKS2
Band10q23.32Start91,798,312 bp[1]
End91,865,276 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 91.8 – 91.87 MbChr 19: 36.83 – 36.89 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.[5]


TNKS2 has been shown to interact with GRB14,[6] TERF1[7][8][9] and Cystinyl aminopeptidase.[8][9][10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107854 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024811 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2".
  6. ^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.
  7. ^ Cook, Brandoch D; Dynek Jasmin N; Chang William; Shostak Grigoriy; Smith Susan (January 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. United States. 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745.
  8. ^ a b Chi, N W; Lodish H F (Dec 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. UNITED STATES. 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
  9. ^ a b Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. England. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774.
  10. ^ Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. United States. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.

Further reading[edit]